Nanomechanics of polymer gels and biological tissues: A critical review of analytical approaches in the Hertzian regime and beyond
نویسندگان
چکیده
We survey recent progress in the application of nanoindentation to characterize the local mechanical properties of polymer gels and biological tissues. We review the theories, analytical models based thereon, and data processing techniques commonly used to determine elastic properties of these classes of materials by instrumented nanoindentation. Examples from the testing of synthetic and biological gels are used to illustrate the limitations of existing theories and approaches. Emphasis is placed on the need for contact mechanics models that more accurately represent the large-strain behaviour of soft matter.
منابع مشابه
Spherical indentation of soft matter beyond the Hertzian regime: numerical and experimental validation of hyperelastic models.
The lack of practicable nonlinear elastic contact models frequently compels the inappropriate use of Hertzian models in analyzing indentation data and likely contributes to inconsistencies associated with the results of biological atomic force microscopy measurements. We derived and validated with the aid of the finite element method force-indentation relations based on a number of hyperelastic...
متن کاملThe Study of Variation of Photon Intensity Inside Biological Phantom by Green Theorem
The Image reconstruction is an important problem in optical tomography. The process of the image processing requires the study of photon migration in biological tissue. There are several approaches to study and simulate propagation of photons in biological tissues. These approaches are categorized into stochastic and analytical groups. The Monte Carlo method as a stochastic method is widely use...
متن کاملMeasurement of absorbed dose in normoxic polymer gel and study of gold nanoparticles configuration effects
Radiotherapy includes all methods that can deliver a particular amount of ionizing radiation to malignant tissues, assuming that minimal damage hurts healthy tissues. We are looking for a valuable and reliable method to measure absorbed dose and the ability to measure the distribution of absorbed dose in three dimensions which nowadays is one of the three-dimensional dosimetry methods in using ...
متن کاملOptical Characterization of NIPAM and PAGAT Polymer Gels for Radiation Dosimetry
Introduction The purpose of the current study was to determine optical sensitivity of N-isopropyl acrylamide NIPAM and polyacrylamide gelatin and tetrakis hydroxymethyl phosphoniun chloride (PAGAT) polymer gels for different wavelength of visible light spectrum applied in optical computed tomography method. Materials and Methods NIPAM and PAGAT polymer gels with conventional formulations used f...
متن کاملDose response evaluation of a low density anoxic polymer gel dosimeter using MRI
Background: The human body contains of different tissues and cavities with different physical and radiological properties. Most important among these are tissues and cavities that are radiologically different from water, including lungs, sinuses and bones. Gel dosimetry provides a unique feature to display dose distributions occurring in clinical radiation therapy in three dimensions. Materials...
متن کامل